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In a randomised controlled trial published in the European Journal of Nutrition in 2014, Setria glutathione supplementation demonstrated significant increases in glutathione levels showing a 30% rise in whole blood, a 35% increase in red blood cells and a 260% increase in buccal cells

When GSH levels decrease, the degradation of SLC25A39 stops, leading to a compensatory increase in mitochondrial GSH levels, reestablishing balance and associated with free iron